Gliclazide(21187-98-4)
Lisi o oloa
Gliclazide o se sulfonylurea oral antidiabetic vailaʻau.O se pa'epa'e tioata po'o se pauta tioata, e leai se manogi ma leai se tofo.
Gliclazide o le 2nd generation oral sulfonylurea hypoglycemic agent ma le malosi malosi.O lona faiga e talitutusa ma le toluenosulfonylurea, o lona uiga, e galue i luga o le pancreatic β-cells e faʻaleleia ai le faʻaogaina o le inisalini ma faʻaleleia ai le tuʻuina atu o le inisalini pe a uma ona 'ai le kulukose, lea e le gata ina faʻaleleia ai le metabolism o tagata maʻi suka, ae faʻaleleia pe faʻatuai ai le tupu mai o le maʻisuka. fa'alavelave vascular ma'i suka.
Gliclazide e masani ona faʻaaogaina mo le maʻisuka ituaiga II maʻisuka ma le maʻisuka matua i le mea e le aoga ai meaʻai ma faʻamalositino naʻo ia ma e aunoa ma se faʻaogaina o le ketosis, faʻapea foʻi le faʻaleleia o faʻamaʻi o le fundus ma le metabolic ma vascular dysfunctions i tagata maʻisuka.
Fa'atatauga
Gliclazide e faʻaaogaina mo le puleaina o le hyperglycemia i le gliclazide e tali atu i le maʻisuka o le maʻisuka mautu, vaivai, e le o ketosis, maʻisuka ituaiga 2.E fa'aaogaina pe a le mafai ona pulea le ma'isuka e ala ile fa'atonuga lelei o mea'ai ma fa'amalositino po'o le taimi e le talafeagai ai le togafitiga o le inisalini.
| Su'ega | Fa'amatalaga | I'uga o au'ili'iliga |
| Fa'aaliga | Pa'epa'e pe toetoe a pa'epa'e pauta. | Pa'epa'e pa'epa'e |
| Solubility | E le mafai ona solu i le vai;solu fua i le methylene chloride;itiiti solu i le acetone;solu teisi i le ethanol(96 pasene). | Faʻafetaui manaoga |
| Fa'ailoga | Ole fua ole absorption infrared e fetaui lelei ma le mea na maua ile gliclazide CRS. | Faʻafetaui manaoga |
| Le mama B (Saunia e HPLC) | ≤2ppm | 0.5ppm |
| Metala mamafa | ≤10ppm | <10ppm |
| Mea fa'atatau (Saunia e le HPLC) | Le mama F ≤0.1% | Le maua |
| O mea leaga ta'itasi e le'i fa'ailoaina ≤0.10% | 0.04% | |
| Aotelega o mea le mama e ese mai le F ≤0.2% | 0.11% | |
| Ma'imau ile fa'amago | ≤0.25% | 0.11% |
| Lefulefu sulfated | ≤0.1% | 0.03% |
| Soli totoe (E GC) | Ethyl acetate NMT 2500 ppm | 265ppm |
| N,N-Dimethylformamide NMT 880 ppm | Le maua | |
| Su'ega | 99.0-101.0%, fa'amamago. | 100.0% |
| Fa'ai'uga | O fa'ai'uga o su'ega e fetaui ma le EP8. | |
